首页 > iHuman研究所 > 师资队伍 > 陶厚朝个人简介
陶厚朝    Research Associate Professor
所在学院 iHuman研究所
研究方向 药物化学,化学生物学
联系方式 taohch@@shanghaitech.edu.cn
 
  个人简介  
1999年获得南开大学化学专业学士学位; 2002年获得中国科学院上海有机化学研究所硕士学位; 2007年获得美国Scripps研究所化学博士学位; 2014年加入上海科技大学iHuman研究所
  主要研究内容  
围绕GPCR蛋白结构和功能研究,开发化学小分子工具,发展化学方法标记特定蛋白或细胞,研制相关疾病的治疗药物和诊断试剂。
  代表性论文  
1. Tao, H., Lee, S.C., Moeller, A., Roy, R.S., Siu, F.-Y., Zimmermann, J., Stevens, R.C., Potter, C.S., Carragher, B., Zhang, Q.*, Engineered nanostructured β-sheet peptides protect integral membrane proteins as stable and functional single particles. Nature Methods, 2013, 10, 759-761.

2. Marcoux, J., Wang, S., Politis, A., Reading, E., Ma, J., Biggins, P., Zhou, M., Tao, H., Zhang, Q., Chang, G., Morgner, N.*, Robinson, C.V.*, Mass spectrometry reveals synergistic binding of nucleotides, lipids and drugs to a multidrug resistance efflux pump. Proc. Natl. Acad. Sci. USA 2013, 110, 9704-9709.

3. Tao, H., Fu, Y., Thompson A., Lee, S.C., Mahoney, N., Stevens, R.C., Zhang, Q.*, Synthesis and properties of dodecyl trehaloside detergents for membrane protein studies. Langmuir 2012, 28, 11173-11181.

4. Tao, H., Weng, Y., Zhuo, R., Chang, G., Urbatsch, I.L., Zhang, Q.*, Design and synthesis of selenazole-containing peptides for co-crystallization with P-glycoprotein. ChemBioChem. 2011, 12, 868-873.

5. Elliott I.G., Fuchs, J.R., Blagg, B.S.J., Ishikawa, H., Tao, H., Yuan, Z.-Q., Boger, D.L.*, Intramolecular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-Oxadiazoles. J. Am. Chem. Soc. 2006, 128, 10589-10595.

6. Tao, H., Huang, I., and Boger, D.L.*, Multidrug resistance reversal activity of permethyl ningalin B amide derivatives. Bioorg. Med. Chem. Lett. 2004, 14, 5979-5981;

7. Yu, B.* and Tao, H., Glycosyl trifluoroacetimidates. 2. Synthesis of Dioscin and Xiebai Saponin I. J. Org. Chem. 2002, 67, 9099-9102;

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