首页 > 生命学院 > 师资队伍 > 张雷个人简介
张雷    特聘教授
所在学院 生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向 发育过程的组织分化与生长调控(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式 rayzhang@@sibcb.ac.cn
备注 百人
 
  主要研究内容  
一直从事组织、器官发育的信号转导调控研究,并在Hippo信号通路、Hh信号通路以及Wg/Wnt等信号通路的调节机制研究中取得过突破性进展,迄今共发表相关研究论文33及综述4篇。2009年回国建立独立实验室以来,主要从事Hippo信号的研究工作,取得了若干突破性进展,以通讯作者或共同通讯作者身份在eLife,PLoS Biol,Cancer Cell,Nat Commun,Cell Res等期刊上发表研究论文17篇及应邀综述2篇,申请共同专利1项。
  代表性论文  
1. Hongling Huang, Shimin Wang, Mengxin Yin,Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao#, Xin-Yuan Liu# and Lei Zhang# Par-1 regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association. PLoS Biology 2013,11(4) e1001620 (Press released by PLoS Biology)(# corresponding author)
2. Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S. Ho, Hongbin Ji, Yun Zhao#, Lei Zhang# Brahma is essential for Drosophila Intestinal Stem Cell proliferation and regulated by Hippo signaling. eLife 2013 2: e00999 (# corresponding author)
3. Tong Guo, Yi Lu, Peixue Li, Meng-Xin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao#, Lei Zhang# A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Research 2013,23:1201-1214(# corresponding author)
4. Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji#, Lei Zhang#, Zhaocai Zhou#. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell 2014, 25: 166-180 (# corresponding author)
5. Yijun Gao, Wenjing Zhang, Xiangkun Han, Fuming Li, Xujun Wang, Rui Wang, Zhaoyuan Fang, Xinyuan Tong, Shun Yao, Fei Li, Yan Feng, Yihua Sun, Yingyong Hou, Zhongzhou Yang, Kunliang Guan, Haiquan Chen, Lei Zhang# & Hongbin Ji# YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nat Communications 2014, 5:4629 (# corresponding author)
浏览次数:3522