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周兆才    特聘教授
所在学院 生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向 癌症与炎症信号机制(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式 zczhou@@sibcb.ac.cn
备注 百人
 
  主要研究内容  
回国近5年来围绕STRIPAK超分子复合物,开展癌症与炎症信号机制研究,获得了前沿性成果:(1)解析STRIPAK复合物装配的基本结构特征,定义其整体不对称性以及激酶招募方式(论文以通讯作者发表在J Biol Chem,2014a;Cell子刊Structure,2013b;受邀发表综述在Curr Chem Biol, 2012);(2)系统揭示STRIPAK复合物激酶组分MST的活性调控机制,并探讨其在细胞生长和迁移中功能作用(论文以通讯作者发表在J Biol Chem,2014b;J Struct Biol, 2014;Cell子刊Structure,2013a;受邀发表综述在Cell Mol Immunol, 2012);(3)发现STRIPAK激酶组分MST信号通路(Hippo通路)中原癌蛋白YAP的一个天然拮抗蛋白VGLL4,解析三维结构,揭示功能机制,并设计发展了YAP的靶向抑制剂,为针对YAP/VGLL4比率失调的癌症提供一种新的个性化诊疗策略及途径(论文以通讯作者发表在Cancer Cell,2014,获Nature China专评;以共同通讯作者发表在Cell Res,2014;受邀发表综述在Acta Biochimica et Biophysica Sinica, 2014;以第一发明人申请专利1项)。
  代表性论文  
1) Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji*, Lei Zhang*, Zhaocai Zhou*. Gastric Cancer Therapy by a Peptide Mimicking VGLL4 Function as a YAP Antagonist. Cancer Cell, 2014, 25: 166-180 (Highlighted by Nature China)
2) Wenjing Zhang, Yijun Gao, Peixue Li, Zhubing Shi, Tong Guo, Fei Li, XiangKun Han, Yan Feng, Chao Zheng, Zuoyun Wang, Haiquan Chen, Zhaocai Zhou*, and Lei Zhang*, Hongbin Ji*. Identification of VGLL4 as a new tumor suppressor in lung cancer negatively regulating the YAP-TEADs transcriptional complex. Cell Res, 2014, 24: 331-343
3) Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guoguang Liu, Cuicui Chen, Miao Feng, Qiao Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang*, Zhaocai Zhou*. Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure, 2013, 21: 680-688
4) Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Lei Zhang, Yun Zhao*, Zhaocai Zhou*. Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure, 2013, 21: 449-561
5) Wenjia Wang, Zhubing Shi, Shi Jiao, Cuicui Chen, Huizhen Wang, Guoguang Liu, Qiang Wang, Yun Zhao, Mark I. Greene, Zhaocai Zhou*. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Res, 2012, 22: 1440-1452 (Cover story; Highlighted by AIMBN)
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