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王明伟    特聘教授
所在学院 生命科学与技术学院
中科院上海药物研究所
研究方向 药物发现(中科院上海药物研究所研究员)
联系方式 mwwang@@simm.ac.cn
 
  代表性论文  
1)Qing Liu, Na Li, Yunyun Yuan, Huili Lu, Xiaoyan Wu, Caihong Zhou, Min He, Haoran Su, Meng Zhang, Jia Wang, Bao Wang, You Wang, Dawei Ma, Yang Ye, Hans-Christoph Weiss, Ernst R.F. Gesing, Jiayu Liao and Ming-Wei Wang (2012). Cyclobutane derivatives as novel non-peptidic small molecule agonists of glucagon like peptide-1 receptor. J. Med. Chem., 55, 250-267.<
2)Anuradha Kumara, Meng Zhang, Linyun Zhu, Charles Mutai, Shittu Hafsat, David R. Sherman and Ming-Wei Wang (2012). High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity. PLoS ONE, 7, e39961 (DOI: 10.1371/journal.pone.0039961). <
3)Caihong Zhou, Yang Feng, Yan Zhou, Jinglun Xue, Yani Chen, Richard D. Ye and Ming-Wei Wang (2013). V101L of human formyl peptide receptor 1 (FPR1) increases the receptor affinity and augments the antagonism mediated by cyclosporins. Biochem. J., 451 (part 2), 245-255.<
4)Fai Yiu Siu, Min He, Chris De Graaf, Gye Won Han, Dehua Yang, Zhiyun Zhang, Caihong Zhou, Qingpin Xu, Daniel Wacker, Jeremiah S. Joseph, Wei Liu, Jesper Lau, Vadim Cherezov, Vsevolod Katritch, Ming-Wei Wang and <
Raymond C. Stevens (2013). Structure of the human glucagon class B G-protein-coupled receptor. Nature, 499, 444-449.<
5)Gregory J. Crowther, Amy M. Fife, Min He, Ting Li, Sylvine Raverdy, Jacopo Novelli, Panqing He, Natalie R. Grattan, Robert H. Barker, Martin L. Kramer, Wesley C. Van Voorhis, Clotilde K.S. Carlow, Michael L. Booker and Ming-Wei Wang (2014). Cofactor-independent phosphoglycerate mutase from nematodes has poor druggability, as revealed by two high-throughput screens. PLoS Negl. Trop.Dis., 8, e2628 (doi:10.1371/journal.pntd.0002628).<

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