1 Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Zhang LN, Wu F, Zhou HY, Fu YY, Li YY, Gu M, Wu LY, Xia CM, Dong TC, Li JY, Shen JK, Li J*. Diabetes. 2013. 62(4):1297-1307.
2 A high-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Qiu BY, Turner N, Li YY, Gu M, Huang MW, Wu F, Pang T, Nan FJ, Ye JM, Li JY*, Li J*. Diabetes 2010, 59:256-265.
3 AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by AICAR and glucose deprivation by down-regulating phsopho-retinoblastoma and cyclin D. Zang Y, Yu LF, Nan FJ, Feng LY, Li J*. J Biol Chem 2009,284:6175-6184.
4 Small molecule antagonizes autoinhibition and activates AMP activated protein kinase in cells. Pang T, Zhang ZS, Gu M, Qiu BY, Yu LF, Cao PR, Shao W, Su MB, Li JY, Nan FJ*, Li J*. J Biol Chem 2008, 283:16051-16060.
5. Berberine, and its more biologically available derivative dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMPK and improve insulin action. Turner N, Li JY, Gosby A, To S, Cheng Z, Miyoshi H, Taketo M, Cooney G, Kraegen E, David J, Hu LH*, Li J*. Diabetes. 2008. 57(5):1414-1418.