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沈旭    特聘教授
所在学院 生命科学与技术学院
中科院上海药物研究所
研究方向 分子药理学(中科院上海药物研究所研究员)
联系方式 xshen@@mail.shcnc.ac.cn
备注 杰青
 
  主要研究内容  
主要从事药物设计学、细胞分子生物学和化学生物学等领域研究。
  代表性论文  
1. Zhang H, Zhou R, Li L, Chen J, Chen L, Li C, Ding H, Yu L, Hu L, Jiang H, Shen X*. Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem. 2011, 286, 1868-75.
2. Tang X, Zhuang J, Chen J, Yu L, Hu L, Jiang H, Shen X*. Arctigenin efficiently enhanced sedentary mice treadmill endurance. PLoS One. 2011, 6(8):e24224.
3. Zhu Z, Li C, Wang X, Yang Z, Chen J, Hu L, Jiang H, Shen X*. 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice. J Neurochem. 2010, 114, 374-85.
4. Hu T, Wu D, Chen J, Ding J, Jiang H, Shen X*. The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis. J Biol Chem. 2008, 283, 21284-93.
5. Chen S, Hu T, Zhang J, Chen J, Chen K, Ding J, Jiang H, Shen X*. Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations. J Biol Chem. 2008, 283, 554-64.
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