首页 > 生命学院 > 师资队伍 > 张旭个人简介
张旭    特聘教授
所在学院 生命科学与技术学院
中科院上海生命科学研究院神经科学研究所
研究方向 神经生物学(中科院上海生命科学研究院神经科学研究所研究员)
联系方式 xu.zhang@@ion.ac.cn
备注 中国科学院院士、杰青
 
  主要研究内容  
1. 痛觉等躯体感觉调控机制;2. 神经递质受体转运调控机制;3. 感知觉的形成机理。
  代表性论文  

1. Li C-L., Li K-C., Wu D., Chen Y., Luo H., Zhao J-R., Wang S-S., Sun M-M., Lu Y-J., Zhong Y-Q., Hu X-Y., Hou R., Zhou B-B., Bao L., Xiao H-S., and Zhang X. (2015) Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res., 26: 83-102.

2. Liu H., Wu Q-F., Li J-Y., Liu X-J., Li K-C., Zhong Y-Q., Wu D., Wang Q., Lu Y-J., Bao L., and Zhang X. (2015) Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles. J. Mol. Cell Biol., 7: 466-475.

3. Ma X-L., Zhang F-X., Dong F., Bao L., and Zhang X. (2015) Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin. Mol. Pain, 11: 22

4. Wang F., Cai B., Li K-C., Hu X., Lu Y., Wang Q., Bao L., and Zhang X. (2015) FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation. Cell Res., 25: 318-334.

5. Zhang X., Bao L., Li S. (2015) Opioid receptor trafficking and interaction in nociceptors. Br. J. Pharmacol., 172: 364–374.

6. Zhang X., Bao L., Yang L., Wu Q-F., and Li Shuai. (2012) Roles of intracellular fibroblast growth factors in neural development and functions. Sci. China Life Sci., 55: 1038-1044. (Review)

7. Wu Q-F., Yang L., Li S., Wang Q., Yuan X-B., Gao X., Bao L., and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149:1549-1564.

8. Zhang X. and Bao L. (2012) Interaction and regulatory functions of μ- and δ-opioid receptors in nociceptive afferent neurons. Neurosci. Bull., 28: 121-130. (Review)

9. Liu X-J., Zhang F-X., Liu H., Li K-C., Lu Y-J., Wu Q-F., Li J-Y., Wang B., Wang Q., Lin L-B., Zhong Y-Q., Xiao H-S., Bao L., and Zhang X.(2012)Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain, 135: 391-403.

10. Li K-C., Wang F., Zhong Y-Q., Lu Y-J., Wang Q., Zhang F-X., Xiao H-S., Bao L., and Zhang X. (2011) Reduction of follistatin-like 1 in primary afferent neurons contributes to neuropathic pain hypersensitivity. Cell Res., 21:697-699.

11. Li K-C., Zhang F-X., Li C-L., Wang F., Yu M-Y., Zhong Y-Q., Zhang K-H., Lu Y-J., Wang Q., Ma X-L., Yao J-R., Wang J-Y., Lin L-B., Han M., Zhang Y-Q., Kuner R., Xiao H-S., Bao L., Gao X., and Zhang X. (2011) Follistatin-like 1 suppresses sensory afferent transmission by activating Na+,K+-ATPase. Neuron, 69: 974-987.

12. Zhao B., Wang H-B., Lu Y-J., Hu J-W., Bao L., and Zhang X. (2011) Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles. Cell Res., 21: 741-753.

13. He S-Q., Zhang Z-N., Guan J-S., Liu H-R., Zhao B, Wang H-B., Li Q., Yang H., Luo J., Li Z-Y., Wang Q., Lu Y-J., Bao L., and Zhang X. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131.

14. Zhong Y-Q., Li K-C., and Zhang X. (2010) Potentiation of excitatory synaptic transmission in substantia gelatinosa neurons of adult rat spinal cord by inhibition of estrogen receptor α. Mol. Pain, 6: 92.

15. Zhang F-X., Liu X-J., Gong L-Q., Yao J-R., Li K-C., Li Z-Y., Lin L-B., Lu Y-J., Xiao H-S., Bao L., Zhang X-H., and Zhang X. (2010) Inhibition of inflammatory pain by activating B-Type natriuretic peptide signal pathway in nociceptive sensory neurons. J. Neurosci., 30: 10927-10938.

16. Wang H-B., Zhao B., Zhong Y-Q., Li K-C., Li Z-Y., Wang Q., Lu Y-J., Zhang Z-N., He S-Q., Zheng H-C., Wu S-X., Hökfelt T-G., Bao L., and Zhang X. (2010) Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons. Proc. Natl. Acad. Sci. USA, 107: 13117-13122.

17. Zhang X. (2010) Pain research in China. Sci. China Life Sci., 53: 356-362. (Review)

18. He S-Q., Yao J-R., Zhang F-X., Wang Q., Bao L., and Zhang X. (2010) Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons. Mol. Pain, 6: 23.

19. Zhang X., Bao L., and Ma G-Q. (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathway. Progress in Neurobiology. 90: 276-283. (Review)

20. Wang L-H., Lu Y-J., Bao L., and Zhang X. (2007) Peripheral nerve injury induces reorganization of galanin-containing afferents in the superficial dorsal horn of monkey spinal cord. Eur. J. Neurosci., 25, 1087-1096.

21. Zhang X., Bao L., and Guan J-S. (2006) Role of delivery and trafficking of δ-opioid peptide receptors in opioid analgesia and tolerance. Trends in Pharmacol. Sci., 27, 324-329. (Review)

22. Sun T., Xiao H-S., Lu Y-J., Zhou P-B., Lu Y-J., Bao L., and Zhang X. (2006) Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury. Neuroscience, 141, 1233-1245.

23. Zhang X. and Bao L. (2006) The development and modulation of nociceptive circuitry. Curr. Opin. Neurobiol., 16, 460-466 (Review)

24. Guan J-S., Xu Z-Z., Gao H., He S-Q., Ma G-Q., Sun T., Wang L-H., Zhang Z-N., Lena I., Kitchen I., Elde R., Zimmer A., He C., Pei G., Bao L. and Zhang X. (2005) Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell, 122, 619-631.

25. Zhang X. and Xiao H-S. (2005) Gene array analysis to determine the components of neuropathic pain signaling. Curr. Opin. Mol. Ther., 7, 532-537. (Review)

26. Yang L., Zhang F-X., Huang F., Lu Y-J., Li G-D., Bao L., Xiao H-S., and Zhang X. (2004) Peripheral axotomy induces trans-synaptic modification of channels, receptors and signaling pathways in rat dorsal spinal cord. Eur. J. Neurosci., 19, 871-883.

27. Bao L., Jin S-X., Zhang C., Wang L-H., Xu Z-Z., Zhang F-X., Wang L-C., Ning F-S., Cai H-J., Guan J-S., Xiao H-S., Xu Z-Q., He C., Hökfelt T., Zhou Z., and Zhang X. (2003) Activation of delta-opioid receptors induces receptor insertion and neuropeptide secretion. Neuron, 37, 121–133.

28. Xiao H-S., Huang Q-H., Zhang F-X., Bao L., Lu Y-J., Guo C., Yang L., Huang W-J., Fu G., Xu S-H., Cheng X-P., Yan Q., Zhu Z-D., Zhang X., Chen Z., Han Z-G., and Zhang X. (2002) Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc. Natl. Acad. Sci. USA., 99, 8360-8365.

29. Bao L., Wang H-F., Cai H-J., Tong Y-G., Jin S-X., Lu Y-J., Grant G., Hökfelt T., and Zhang X. (2002) Peripheral axotomy induces only very limited sprouting of coarse myelinated afferents into inner lamina II of rat spinal cord. Eur. J. Neurosci., 16, 175-185.

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