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周保罗    特聘教授
所在学院 生命科学与技术学院
中科院上海巴斯德研究所
研究方向 抗病毒免疫、HIV、流感病毒(中科院上海巴斯德研究所研究员)
联系方式 blzhou@@sibs.ac.cn
 
  主要研究内容  
1. 抗流感和HIV 包膜蛋白的人源单克隆抗体的研究。 2. GPI锚定抗体衍生物。 3. 基于流感和HIV 病毒包膜蛋白广谱免疫原的研究和开发。
  代表性论文  
1. Wen, M., Arora, R., Wang, H., Liu, L., Kimata, J.T., and Zhou, P. GPI-anchored single chain Fv - an effective way to capture transiently-exposed neutralization epitopes on HIV-1 envelope spike. Retrovirology. 7:79-90, 2010.
2. Liu, L.H., Wen, M., Wang, W.M., Wang, S.M., Yang, L.F., Liu,Y., Qian, M.R.,Zhang, L.Q., Shao, Y.M., Kimata, J.T., and Zhou, P. Potent and broad anti-HIV-1 activity exhibited by a glycosyl-phosphatidylinositol-anchored peptide derived from the CDR H3 of broadly neutralizing antibody PG16. J. Virol. 85:8467-8476, 2011.
3. Hu, H.X., Voss, J.E., Zhang, G., Buchy, P., Zuo, T., Wang, L.L., Wang, F., Zhou, F., Wang, G.Q., Tsai, C., Calder, L., Gamblin, S.J., Zhang, L.Q., Deubel, V., Zhou, B.P., Skehel, J.J., and Zhou, P. A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses. J. Virol. 86:2978-2989, 2012.
4. Yang, L.F., Song, Y.F., Li, X.M., Huang, X.X., Liu, J.J., Ding, H., Zhu, P., and Zhou, P. HIV-1 virus-like particles produced by stably transfected Drosophila S2 cells: a desirable vaccine component. J Virol. 86:7662-76, 2012.
5. Zhou, F., Wang, G.Q., Buchy, P., Cai, Z.P., Chen, H.L., Chen, Z.W., Cheng, G.H., Wan, X-F., Deubel, V., and Zhou, P. A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of HPAI H5N1 viruses. J Virol. 86:6970-8,2012.
6. Liu, L.H., Wang, W.M., Yang, L.F., Ren, H.H., Kimata, J.T., and Zhou, P. Trimeric GPI-HCDR3 of broadly neutralizing antibody PG16 is a potent HIV-1 entry inhibitor. J Virol. 2013. 87(3):1899-1905.
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