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徐国良    特聘教授
所在学院 生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向 表观遗传调控(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式 glxu@@sibcb.ac.cn
备注 中国科学院院士、杰青、百人
 
  主要研究内容  
实验室致力于探索:DNA甲基化谱式是如何在胚胎发育早期建立起来的?是否存在新的碱基修饰形式?胚胎干细胞与成体干细胞自我更新与分化是如何达到平衡的?哪些因素导致了 这一平衡的改变而导致肿瘤和疾病发生?对表观遗传信息调控的研究将有助于了解生长发育与疾病发生发展的分子机理,为维护人类健康尤其是再生医学的技术开发提供理论依据。
  代表性论文  
1. Hui Yang, Linyu Shi, Bangan Wang,Dan Liang, Cuiqing Zhong, Wei Liu, Yongzhan Nie, Jie Liu, Jing Zhao, Xiang Gao, Dangsheng Li, Guoliang Xu* and Jinsong Li*. (2012) Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell 149,605-617. (* co-corresponding author)
2. Tian-Peng Gu, Fan Guo, Hui Yang, Hai-Ping Wu, Gui-Fang Xu, Wei Liu, Zhi-Guo Xie, Linyu Shi, Xinyi He, Seung-gi Jin, Khursheed Iqbal, Yujiang Geno Shi, Zixin Deng, Piroska E. Szabó, Gerd P. Pfeifer, Jinsong Li* and Guo-Liang Xu*. (2011) The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477, 606-610.
3. Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li, Yan Sun, Xiuxue Li, Qing Dai, Chun-Xiao Song, Kangling Zhang, Chuan He and Guo-Liang Xu. (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333, 1303–1307.
4. Yang Wang, Jiekai Chen, Jia-Lei Hu, Xi-Xiao Wei, Dajiang Qin, Juan Gao, Lei Zhang, Jing Jiang, Jin-Song Li, Jing Liu, Ke-Yu Lai, Xia Kuang, Jian Zhang, Duanqing Pei and Guo-Liang Xu. (2011) Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Reports 12, 373–378.
5. Jia-Lei Hu, Bo O. Zhou, Run-Rui Zhang, Kang-Ling Zhang, Jin-Qiu Zhou* and Guo-Liang Xu* (2009) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. PNAS 106, 22187–22192.
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