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谢东    特聘教授
所在学院 生命科学与技术学院
中科院上海生命科学研究院营养科学研究所
研究方向 肿瘤分子生物学(中科院上海生命科学研究院营养科学研究所研究员)
联系方式 dxie@@sibs.ac.cn
备注 杰青、百人
 
  主要研究内容  
肿瘤发生、转移及肿瘤代谢的分子机制。利用分子生物学,细胞生物学以及动物模型研究肿瘤发生、转移及肿瘤代谢的作用机理和信号转导。
  代表性论文  
1. Yang P, Li QJ, Feng Y, Zhang Y, Deng Y, Zhao J, Jiang S, Wang HY, Cheng SQ Dong Xie*, Wang XF. TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma. Cancer Cell 11:22 291-303, 2012
2. Guo Li, Xiao-Dan Ji, Hong Gao, Jiang-Sha Zhao, Jun-Feng Xu, Zhi Jian Sun, Yue-Zhen Deng, Shuo Shi, Jing-Jing Li and Dong Xie*. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. Nature Communications. doi:10.1038/ncomms1675, 2012
3. Yue-Zhen Deng, Fan Yao, Jing-Jing Li, Zheng-Fa Mao, Ping-Ting Hu, Ling-Yun Long, Guo Li, Yong Liu, Xiang Du, Ming-zhou Guo, Li-Yan Xu, En-Min Li, Hong-Yang Wang and Dong Xie*. RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the β-Catenin Destruction Complex. Gastroenterology. 142(4):812-823, 2012
4. Yu-Xiong Feng, Tao Wang, Pengyuan Yang, Jing-Jing Li, Yue-Zhen Deng, Fan Yao, Hui Wang, Nan Li, Meng-Chao Wu, Hong-Yang Wang, Xiao-Fan Wang, Shu-Qun Cheng and Dong Xie* Sorafenib Suppresses Postsurgical Recurrence and Metastasis of hepatocellular carcinoma in an orthotopic mouse model.. Hepatology 53(2):483-92, 2011
5. Yu-Xiong Feng, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng Yunfei Yuan, Xiao-Fan Wang and Dong Xie*. Liver Cancer:EphrinA2 Promotes Tumorigenicity through Rac1/Akt/NF-kappaB Signaling Pathway 120:. Hepatology 51(2): 535-544, 2010
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