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魏万国    特聘教授
所在学院 生命科学与技术学院
中科院上海高等研究院
研究方向 化学生物学(中科院上海高等研究院研究员)
联系方式 weiwg@@sari.ac.cn
备注 百人
 
  主要研究内容  
针对重要生物活性的天然产物发展高效的合成方法学;以原创性的药物分子为导向,运用多样性导向的合成策略发现新型药物先导化合物。发展新的细胞筛选方法来发现能够调控干细胞命运的生物活性分子;运用化学生物学手段进行干细胞命运调控的分子机制研究。
  代表性论文  
1. Li, W.-L., Sun, W., Zhang, Y., Wei, W.-G., Ambasudhan, R., Xia, P., Talantova, M., Lin, T.-X., Kim, J.-W., Wang, X.-L., Kim, W.-R., Lipton, S. A., Zhang, K., Ding, S. Rapid induction and long-term self-renew of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc. Natl. Acad. Sci. USA, 2011, 108, 8299-8304.
2. Brown, L. E., Cheng, K. C.-C., Wei, W.-G., Yuan, P.-W., Dai, P., Trilles, R., Ni, F., Yuan, J., MacArthur, R., Guha, R., Johnson, R. L., Su, X.-Z., Dominguez, M. M., Snyder, J. K., Beeler, A. B., Schaus, S. E., Inglese, J., Porco, J. A., Jr. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc. Natl. Acad. Sci. USA, 2011, 108, 6775-6780.
3. Xu, Y., Zhu, X.-W., Hahm, H.-S., Wei, W.-G., Hao, E.-G., Hayek, A., Ding, S. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. USA, 2010, 107, 8129-8134.
4. Wei, W.-G., Cai, C., Kota, S., Takahashi, V., Ni, F., Strosberg, A. D., Snyder, J. K. New Small Molecule Inhibitors of Hepatitis C Virus. Bioorg. Med. Chem. Lett. 2009, 19, 6926-6930.
5. Qian, W.-J., Wei, W.-G., Zhang, Y.-X., Yao, Z.-J. Total synthesis, assignment of absolute stereochemistry, and structural revision of chlorofusin. J. Am. Chem. Soc. 2007, 129, 6400-6401.
6. Wei, W.-G., Yao, Z.-J. Synthesis studies toward chloroazaphilone and vinylogous γ-pyridones: two common natural products core structures. J. Org. Chem. 2005, 70, 4585-4590.
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